%0 Journal Article %T Pharmacokinetics of harringtonine liposomes in rabbits %A Wu Huai-liang %A Weng Guo-ying %A Wu Zhao-hui %A Lu You-cai %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Pharmacokinetics of harringtonine liposomes in rabbits %K %X After i.v. free harringtonine (FH) and harringtonine liposomes (HL) with high and low encapsulation percentage (En%) to rabbits, their blood concentrations were determined by reverse-phase HPLC. The blood concentration-time curves were shown to fit a two-compartments open model. FH: T1/2 alpha = 1.32 +/- 0.24, T1/2 beta = 32 +/- 6 min; Low En % HL: T1/2 alpha = 4.12 +/- 0.25, T1/2 beta = 106 +/- 5 min; High En % HL: T1/2 alpha = 9.4 +/- 1.2, T1/2 beta = 209 +/- 5 min %U http://www.chinaphar.com/article/view/6039 %V 15 %N 1 %P 84-86 %@ 1745-7254