@article{APS6035,
author = {Jian-shi Zhang and You-yi Liang and Xue-ming Yan},
title = {Whole-body autoradiographic localization of catecholamic acid in mice},
journal = {Acta Pharmacologica Sinica},
volume = {15},
number = {1},
year = {2016},
keywords = {},
abstract = {Catecholamic acid [catechol-3,6-bis-(methyleneimino diacetic acid)] is a chelating agent synthesized in our institute. Whole-body autoradiographic study was carried out to determine the distribution of [14C]catecholamic acid in 5 adult male mice. Each mouse was injected i.v. 370 kBq. After various times the mice, under ether anesthesia, were immersed in a mixture of dry ice and hexane. Whole-body sections were made at -20 C, 20 microns in thickness. Results showed: (1) At 5 min, higher radioactivities appeared in blood, kidneys, gastrointestinal mucosa, bone, skin, and hair; moderate concentrations in liver, lungs, spleen, and salivary glands. (2) During 20 min and 3 h, the radioactivities decreased (gradually) in all tissues except the bone. (3) Intense radioactivity persisted in the bone, while only traces remained in the kidneys and intestinal mucosa throughout the 24 h period of observation},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6035}
}