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Effects of methylflavonolamine hydrochloride on contractility of isolated rabbit ileum

   
@article{APS6018,
	author = {Ping Long and Chao-Hua Yan and Ming-Sheng Zhang and Ee-Feng Zhou},
	title = {Effects of methylflavonolamine hydrochloride on contractility of isolated rabbit ileum},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {Methylflavonolamine hydrochloride (MFA), verapamil (Ver), and trifluoperazine (Tri) inhibited the contractions induced by submaximal concentrations of acetylcholine (ACh) and serotonin (5-HT). IC50 values (mumol.L-1) were 33.2 +/- 0.7, 0.276 +/- 0.018, 3.83 +/- 0.23, and 15.31 +/- 0.10, 0.233 +/- 0.017, 2.33 +/- 0.20, respectively. MFA, Ver, and Tri inhibited the contractions induced by CaCl2 and pD'2 values were 4.3 +/- 0.3, 6.23 +/- 0.22, 4.99 +/- 0.24, respectively. MFA 3 mumol.L-1, Ver 0.03 mumol.L-1, and Tri 3 mumol.L-1 inhibited the contractions induced by ACh in Ca(2+)-free medium, while MFA 60 mumol.L-1, Tri 30 mumol.L-1, but not Ver 0.6 mumol.L-1, had pronounced inhibitions on extracellular calcium-dependent contractions induced by ACh. These results suggest that MFA has a calcium antagonistic effect and that MFA is similar to Tri, but not Ver, in mechanism.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6018}
}