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Inhibitory effect of 0,0-bisacetyldaurisoline on Ca2+ influx into synaptosomes

   
@article{APS5988,
	author = {You-ming Lu and Guo-qing Liu},
	title = {Inhibitory effect of 0,0-bisacetyldaurisoline on Ca2+ influx into synaptosomes},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {The inhibitory effects of 0,0-bisacetyldaurisoline (BDSL) on 45Ca2+ uptake and [3H]GABA release from synaptosomes were investigated. BDSL (1-100 mumol.L-1) produced a concentration-related inhibition of high K(+)-stimulated 45Ca2+ uptake and [3H]GABA release (IC50 = 5.6 +/- 0.7 and 31.4 +/- 2.3 mumol.L-1, respectively) in synaptosomes but verapamil (Ver) was only weakly active. Neither BDSL (100 mumol.L-1) nor Ver (100 mumol.L-1) modified 45Ca2+ uptake in control medium (K+ 5 mmol.L-1 resting uptake) and [3H]GABA release in Ca(2+)-free medium (K+ 45 mmol.L-1 basal release). The results suggest that BDSL may be a potent Ca2+ channel blocker in neurons.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5988}
}