%0 Journal Article %T Exhaustive swimming differentially inhibits P2X 1 receptor- and α 1 -adrenoceptor-mediated vasoconstriction in isolated rat arteries %A Li Lu %A Wu Tao %A Wei Cong %A Han Jian-ke %A Jia Zhen-hua %A Wu Yi-ling %A Ren Lei-ming %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Exhaustive swimming differentially inhibits P2X 1 receptor- and α 1 -adrenoceptor-mediated vasoconstriction in isolated rat arteries %K %X Aim: To investigate the effects of exhaustive swimming exercise on P2X 1 receptor- and α 1 -adrenoceptor-mediated vasoconstriction of different types of arteries in rats. Methods: Male Wistar rats were divided into 2 groups: the sedentary control group (SCG) and the exhaustive swimming exercise group (ESEG). The rats in the ESEG were subjected to a swim to exhaustion once a day for 2 weeks. Internal carotid, caudal, pulmonary, mesenteric arteries and aorta were dissected out. Isometric vasoconstrictive responses of the arteries to α,β-methylene ATP (α,β-MeATP) or noradrenaline (NA) were recorded using a polygraph. Results: The exhaustive swimming exercise did not produce significant change in the EC50 values of α,β-MeATP or NA in vasoconstrictive response of most of the arteries studied. The exhaustive swimming exercise inhibited the vasoconstrictive responses to P2X 1 receptor activation in the internal carotid artery, whereas it reduced the maximal vasoconstrictive responses to α 1 -adrenoceptor stimulation in the caudal, pulmonary, mesenteric arteries and aorta. The rank order of the reduction of the maximal vasoconstriction was as follows: mesenteric, pulmonary, caudal, aorta. Conclusion: Exhaustive swimming exercise differentially affects the P2X 1 receptor- and α 1 -adrenoceptor-regulated vasoconstriction in internal carotid artery and peripheral arteries. The ability to preserve purinergic vasoconstriction in the peripheral arteries would be useful to help in maintenance of the basal vascular tone during exhaustive swimming exercise. %U http://www.chinaphar.com/article/view/5978 %V 33 %N 2 %P 221-229 %@ 1745-7254