@article{APS5966,
author = {Yang Li and Ding-guo Yong and Bao-qin Geng and Gang-guo Gu},
title = {Antiulcer action and mechanism of trifluoperazine in rat stomach},
journal = {Acta Pharmacologica Sinica},
volume = {12},
number = {5},
year = {2016},
keywords = {},
abstract = {Trifluoperazine (TFP) 5, 10, 20 mg.kg-1 ig inhibited the formation of gastric ulcers induced by pyloric ligation, stress and indomethacin in rats and showed dose-effect dependence. TFP 10, 20 mg.kg-1 ig depressed the secretion of gastric juice, acid, and pepsin, but TFP 5, 10, 20 mg.kg-1 ig had no influence on the pepsin activity. TFP 20 mg.kg-1 ig inhibited the gastric H+, K(+)-ATPase activity of both stress and indomethacin ulcers in rats in vivo, and the gastric H+, K(+)-ATPase activity was also inhibited by TFP 50 mumol.L-1 in vitro. The results suggested that the inhibition of gastric H+, K(+)-ATPase activity and gastric secretion might be related to the antiulcer mechanism of TFP.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5966}
}