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Low-affinity binding sites of glucocorticoid

   
@article{APS5847,
	author = {Ying-ying Le and Guo-zheng Qian and Li-ming Sui and Qin-zhi Gong and Ren-bao Xu},
	title = {Low-affinity binding sites of glucocorticoid},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {The low-affinity glucocorticoid binding sites (LAGS) with steroid specificity were demonstrated in hepatic cytosol, cerebral cytosol, and thymocytes of rat. The Kd of LAGS was 1-10 mumol.L-1 as estimated by Scatchard, pseudo-scatchard, and competitive analysis. The specific binding of dexamethasone 1-100 nmol.L-1 was roughly parallel with its inhibition of [3H]UdR incorporation in thymocytes of rat, and both were blocked by mifepristone (RU-486), the competitive antagonist of glucocorticoids. These results suggest that the pharmacological activity of glucocorticoid might be mediated at least partially by LAGS.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5847}
}