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Effects of substance P on electric activity of mouse pancreatic islet cells in vitro

   
@article{APS5839,
	author = {Xiao-wen Fu and Xin-ming Shen and Qing-fen Su and Jing-ru Zhang},
	title = {Effects of substance P on electric activity of mouse pancreatic islet cells in vitro},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {The effects of substance P (SP), [D-Pro2, D-Trp7,9]SP and verapamil on the electric activity of B cells of Langerhans islets of mice were investigated. Addition of SP 100 nmol.L-1 to the perfusion medium stimulated spontaneous electric activity induced by glucose 5.5 mmol.L-1 with an increase in frequency and amplitude of the spikes. [D-Pro2, D-Trp7,9]SP 50 nmol.L-1 reversed the stimulative effect of SP. There was no evidence for an enhancing interaction between SP and acetylcholine 1 mumol.L-1. Verapamil 60 mumol.L-1 blocked the stimulative effect of SP. These results suggest that the stimulative effect of SP on the electric activity of B cells may be due to the increase in Ca2+ influx through the voltage-dependent Ca2+ channels.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5839}
}