How to cite item

Effect of intrahippocampal quinolinic acid infusion on the amygdala kindling in rat

   
@article{APS5833,
	author = {Han-xian Ping and Guo-qing Liu and Lin Xie and Hui-qiu Wu},
	title = {Effect of intrahippocampal quinolinic acid infusion on the amygdala kindling in rat},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {The effect of intrahippocampal infusion of quinolinic acid (Quin), an endogenous excitatory amino acid, was studied on the amygdala kindling. Quin 120 nmol injected intrahippocampally 2 wk prior to the beginning of amygdala kindling significantly not only produced dorsal hippocampal pyramidal and granule cell loss but also decreased the number of stimuli to trigger the stage 5 seizures of amygdala kindling. In kindled rats, intrahippocampal 20 nmol Quin infusion fully inhibited the stage 5 of amygdala-kindled seizures. The inhibitory effect of Quin was antagonized by dl-2-amino-7-phosphonoheptanoic acid, a selective antagonist of N-methyl-D-aspartate (NMDA) type receptors. The results suggest that NMDA-type receptors in the hippocampus may play a role in the control of the seizure threshold in the amygdala.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5833}
}