TY - JOUR AU - Zhong Guo-gan AU - Jiang Yan AU - Wang Xue-qing AU - Yue Gang PY - 2016 TI - Effects of panaxadiol and panaxatriol saponins on action potentials of normal and xanthine-xanthine oxidase damaged cultured myocardial cells JF - Acta Pharmacologica Sinica; Vol 12, No 3 (May 1991): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Wistar rat myocardial cells were cultured. PDS 20-80 micrograms.ml-1; PTS 1.25-20 micrograms.ml-1 dose-dependently decreased their action potential parameters, indicating the possibility of being concerned in the blockage of Ca channel. After the free radical damage was induced by xanthine 0.42 mmol.L-1--xanthine oxidase 5.3 nmol.L-1 (X-XO). All the action potential parameters of the cardiac cells decreased without exception. Both PDA and PTS antagonized the electrical appearance of membrane damage induced by X-XO, suggesting that both PDS and PTS protect the myocardial cells from oxidative damage. UR - http://www.chinaphar.com/article/view/5811