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Effect of extracellular calcium on enhancement of norepinephrine release in hippocampus by phorbol ester

   
@article{APS5770,
	author = {Hua-yu HUANG and Shu-ping DAI},
	title = {Effect of extracellular calcium on enhancement of norepinephrine release in hippocampus by phorbol ester},
	journal = {Acta Pharmacologica Sinica},
	volume = {11},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {Rabbit hippocampal slices were preloaded with [3H]norepinephrine ([3H]NE) and superfused with medium. Tetrodotoxin(TTX) inhibited [3H]NE release evoked by high K+, but did not affect on that evoked by Ca(2+)-pulse. The facilitatory effect of phorbol ester (PDB) on high K(+)-evoked [3H]NE release was elevated with increasing extracellular Ca2+ concentration. In the case of Ca(2+)-pulse-evoked [3H]NE release, the enhancement by PDB was decreased with increasing Ca2+ concentration in the extracellular space. It was suggested that the facilitation of Ca(2+)-influx was not involved in the mechanism of action of protein kinase C.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5770}
}