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Effects of phencyclidine on contractile forces of isolated rabbit papillary muscles

   
@article{APS5702,
	author = {Jia-le Dai and Shao-fen Xu},
	title = {Effects of phencyclidine on contractile forces of isolated rabbit papillary muscles},
	journal = {Acta Pharmacologica Sinica},
	volume = {12},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Phencyclidine (PCP) (0.01-50 mumol.L-1) and its analogue, TCP (0.01-50 mumol.L-1) exhibited positive inotropic effects on electrically stimulated rabbit papillary muscle preparations. Dextrorphan (5 or 10 mumol.L-1) antagonized the actions of PCP in non-competitive manner (pD'2 = 5.25). This demonstrated the involvement of PCP receptors in the positive inotropic effects of PCP. By using high performance liquid chromatography with electrochemical detector (HPLC-ECD), an increase of DOPAC content was found in bath medium after PCP addition. Each of the dopamine receptor antagonists SCH23390, haloperidol and sulpiride (1 mumol.L-1) attenuated the maximal inotropic effects of PCP. These results suggest that PCP induces positive inotropic effects by increasing the release and/or blocking the uptake of dopamine.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5702}
}