%0 Journal Article %T Effects of schizandrin B and schisanhenol on drug metabolizing-phase II enzymes and estradiol metabolism %A LU Hua %A LIU Geng-tao %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Effects of schizandrin B and schisanhenol on drug metabolizing-phase II enzymes and estradiol metabolism %K %X Intragastric gavage of schizandrin B (Sin B) and schisanhenol (Sal) 200 mg/kg once daily for 3 d significantly increased liver glutathione-S-transferase (GSH-S-T) and microsomal cytochrome P-450 in mice and rats. Sin B and Sal antagonized the increase of uterus weight induced by sc estradiol in ovariectomized, and decreased serum estradiol level in mice. RIA and HPLC showed an enhancement in [3H] estradiol metabolism by liver microsomes from Sin B- and Sal-treated mice. The results indicated that both Sin B and Sal have inductive actions on drug metabolizing-phase I and phase II enzymes in mice and rats. %U http://www.chinaphar.com/article/view/5678 %V 11 %N 4 %P 331-335 %@ 1745-7254