@article{APS5678,
author = {Hua LU and Geng-tao LIU},
title = {Effects of schizandrin B and schisanhenol on drug metabolizing-phase II enzymes and estradiol metabolism},
journal = {Acta Pharmacologica Sinica},
volume = {11},
number = {4},
year = {2016},
keywords = {},
abstract = {Intragastric gavage of schizandrin B (Sin B) and schisanhenol (Sal) 200 mg/kg once daily for 3 d significantly increased liver glutathione-S-transferase (GSH-S-T) and microsomal cytochrome P-450 in mice and rats. Sin B and Sal antagonized the increase of uterus weight induced by sc estradiol in ovariectomized, and decreased serum estradiol level in mice. RIA and HPLC showed an enhancement in [3H] estradiol metabolism by liver microsomes from Sin B- and Sal-treated mice. The results indicated that both Sin B and Sal have inductive actions on drug metabolizing-phase I and phase II enzymes in mice and rats.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5678}
}