TY - JOUR AU - ZHANG Gui-qing AU - QI Min AU - KE Jun AU - ZHANG Ying-ge PY - 2016 TI - Effects of trihexyphenidyl on basilar artery of rabbits and cerebrovascular circulation of rats JF - Acta Pharmacologica Sinica; Vol 11, No 4 (July 1990): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Trihexyphenidyl (Tri) inhibited the contraction of rabbit basilar artery due to high K+ (45.6 mmol/L). IC50 was 2.9 +/- 0.7 mumol/L. The contractions of basilar and mesenteric arteries due to calcium and those of basilar artery and saphenous vein due to serotonin were noncompetitively. Tri inhibited myogenic activities of the portal vein strips of rats and increased the normal cerebral blood flow of rats to 19 +/- 7 ml/(min.100 g). UR - http://www.chinaphar.com/article/view/5669