@article{APS5660,
author = {Rui-hai An and Rui-rong He},
title = {Electrophysiological effects of m-nisoldipine and nisoldipine on pacemaker cells in sinoatrial node of rabbits},
journal = {Acta Pharmacologica Sinica},
volume = {12},
number = {1},
year = {2016},
keywords = {},
abstract = {The effects of m-nisoldipine (m-Nis) and nisoldipine (Nis) on the electrical activity of pacemaker cells in sinoatrial node (SAN) of rabbit were studied using intracellular microelectrodes. RESULTS: APA and Vmax in SAN pacemaker cells were markedly reduced by m-Nis and Nis. The inhibitory effects of Nis on APA and Vmax were greater than those of the m-Nis. Elevation of Ca2+ concentration in the perfusate partially antagonized the inhibitory actions of m-Nis and Nis. VDD of SAN pacemaker cells were reduced by m-Nis. The change of RPF was not consistent with that of VDD. CSRT was prolonged by m-Nis and Nis in a dose-dependent manner. The inhibitory effects of Nis on SAN pacemaker cells were greater than that of the m-Nis. Both MDP and APD50 were not affected by m-Nis and Nis.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5660}
}