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Pharmacokinetics and autoradiography of [3H] or [14C]stepholidine

	author = {Zhen-de ZHANG and Chen-min ZHOU and Guo-zhang JIN and Xin ZHANG and Liu YANG},
	title = {Pharmacokinetics and autoradiography of [3H] or [14C]stepholidine},
	journal = {Acta Pharmacologica Sinica},
	volume = {11},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {After iv [3H]stepholidine (SPD) 12 MBq/kg, the concentration-time curve in rats was found to be a two-compartment open model. The distribution phase T1/2 alpha = 3.6 min, the elimination phase T1/2 beta = 168 min. The absorbed radioactivities of [3H] SPD in 15-30 min were 80-87%. The amounts of [3H]SPD bound to plasma protein, liver and kidney homogenates were estimated to be 37, 31, and 30%, respectively. During 3 d after ip [3H]SPD 50 MBq/kg, 56% of the radioactivity was excreted in urine and 5% in feces, thus, it suggested that [3H]SPD was mainly excreted by kidneys. After iv a single dose of [14C]SPD in mice, the whole-body autoradiography showed that [14C]SPD was rapidly distributed among various tissues. High radioactivities were found in kidneys, liver, brain, salivary glands, Harder's glands, heart blood and muscle at 2 min and intensively localized in kidneys and stomach mucosa at 30 min. The radioactivities in these tissues disappeared 4 and 8 h later, while that in intestine could not be detected 24 h later.},
	issn = {1745-7254},	url = {}