@article{APS5622,
author = {Dong-ju Jiang and Jing-yi Tao and Shun-yao Xu},
title = {Inhibitory effects of clonidine on edema formation after thermal injury in mice and rats},
journal = {Acta Pharmacologica Sinica},
volume = {10},
number = {6},
year = {2016},
keywords = {},
abstract = {Clonidine 1 mg/kg ip given before thermal injury significantly inhibited the edema formation in mice and rats during the early stage of burn. Clonidine 0.1 mg/kg ip gave no such effect, but it became effective after being administrated via icv. The inhibitory effects of clonidine on edema formation were abolished by pretreatment with yohimbine 5 mg/kg ip, but not with prazosin 10 mg/kg ip. The tracing by 113mIn labelled transferrin demonstrated that clonidine decreased the capillary permeability in burned tissues 1 h after burn. When clonidine 1 mg/kg was given ip to the rats 20 min before burn, it lowered the level of lipoperoxide in the serum 2 h after burn. These results suggest that the inhibitory effects of clonidine on edema formation is most probably due to the depression of sympathetic activity via alpha 2 receptor during thermal injury.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5622}
}