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Effects of FeSO4 on electrical and mechanical activity of guinea pig papillary muscles

   
@article{APS5617,
	author = {Guang-wei Luo and Xiao-guang Li},
	title = {Effects of FeSO4 on electrical and mechanical activity of guinea pig papillary muscles},
	journal = {Acta Pharmacologica Sinica},
	volume = {10},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {FeSO4 0.1-0.7 mmol/L shortened the action potential duration, decreased the action potential amplitude (APA) and maximal upstroke velocity of 0 phase (Vmax), and reduced the contractile force of myocardium in a concentration-dependent manner. FeSO4 0.2 mmol/L depressed the APA and Vmax of papillary muscles in Tyrode's solution containing MnCl2 3 mmol/L, and reduced the APA, Vmax and duration of slow action potentials in potassium-depolarized papillary muscles. These results suggest that Fe2+ may inhibit the transmembrane movement of Ca2+ and Na+ in myocardial cells. This may be one of the mechanisms of heart failure and circulatory collapse in acute iron poisoning.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5617}
}