@article{APS5573,
author = {Hua Yue and Jin-wei He and Hao Zhang and Chun Wang and Wei-wei Hu and Jie-mei Gu and Yao-hua Ke and Wen-zhen Fu and Yun-qiu Hu and Miao Li and Yu-juan Liu and Song-hua Wu and Zhen-lin Zhang},
title = {Contribution of Myostatin gene polymorphisms to normal variation in lean mass, fat mass and peak BMD in Chinese male offspring},
journal = {Acta Pharmacologica Sinica},
volume = {33},
number = {5},
year = {2016},
keywords = {},
abstract = {Aim: Myostatin gene is a member of the transforming growth factor-β (TGF-β) family that negatively regulates skeletal muscle growth. Genetic polymorphisms in Myostatin were found to be associated with the peak bone mineral density (BMD) in Chinese women. The purpose of this study was to investigate whether Myostatin played a role in the normal variation in peak BMD, lean mass (LM), and fat mass (FM) of Chinese men.
Methods: Four hundred male-offspring nuclear families of Chinese Han ethnic group were recruited. Anthropometric measurements, including the peak BMD, body LM and FM were measured using dual-energy X-ray absorptiometry (DXA). The single nucleotide polymorphisms (SNPs) studied were tag-SNPs selected by sequencing. Both rs2293284 and +2278GA were genotyped using TaqMan assay, and rs3791783 was genotyped with PCR-restriction fragment length polymorphism (RFLP) analysis. The associations of the SNPs with anthropometric variations were analyzed using the quantitative transmission disequilibrium test (QTDT).
Results: Using QTDT to detect within-family associations, neither single SNP nor haplotype was found to be associated with peak BMD at any bone site. However, rs3791783 was found to be significantly associated with fat mass of the trunk (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5573}
}