@article{APS5535,
author = {Ming-hua Li and Koichi Inoue and Hong-fang Si and Zhi-gang Xiong},
title = {Calcium-permeable ion channels involved in glutamate receptor-independent ischemic brain injury},
journal = {Acta Pharmacologica Sinica},
volume = {32},
number = {6},
year = {2016},
keywords = {},
abstract = {Brain ischemia is a leading cause of death and long-term disabilities worldwide. Unfortunately, current treatment is limited to thrombolysis, which has limited success and a potential side effect of intracerebral hemorrhage. Searching for new cell injury mechanisms and therapeutic interventions has become a major challenge in the field. It has been recognized for many years that intracellular Ca2+ overload in neurons is essential for neuronal injury associated with brain ischemia. However, the exact pathway(s) underlying the toxic Ca2+ loading remained elusive. This review discusses the role of two Ca2+-permeable cation channels, TRPM7 and acid-sensing channels, in glutamate-independent Ca2+ toxicity associated with brain ischemia.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5535}
}