TY - JOUR AU - Tsui Ke-hung AU - Juang Horng-heng AU - Lee Tsong-hai AU - Chang Phei-lang AU - Chen Chien-lun AU - Yung Benjamin Yat-ming PY - 2016 TI - Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples JF - Acta Pharmacologica Sinica; Vol 29, No 3 (March 2008): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Aim: To investigate the possible correlation of nucleophosmin/B23 expression with bladder carcinoma recurrence. Methods: Surgically-resected bladder tumors staged pTa to pT4 were examined for nucleophosmin/B23 expression by immuno-histochemistry. The study group consisted of 132 consecutive patients surgically treated at Chang Gung Memorial Hospital between December 1998 and November 1999. The mean follow up was 72 months (range: 48-84 months). Results: Nuclear nucleophosmin/B23 staining was detected in 96% of advanced stage and poorly-differentiated tumors. Higher nucleophosmin/B23 levels were linked to more advanced tumor stages, grades, poor prognosis, and likelihood of recurrence ( P P =0.009). Conclusion: The results suggest that nucleophosmin/B23 is a favorable prognostic indicator for bladder cancer. Nucleophosmin/B23 could be a useful molecular tumor marker for predicting bladder cancer recurrence. UR - http://www.chinaphar.com/article/view/5520