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Induction by kopsinine of hepatic mixed-function oxidase in mice

	author = {Wan-yun HUANG and Geng-tao LIU},
	title = {Induction by kopsinine of hepatic mixed-function oxidase in mice},
	journal = {Acta Pharmacologica Sinica},
	volume = {11},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {Kopsinine is an indole alkaloid. Oral administration of kopsinine 200 mg/kg once daily for 3 d significantly increased liver microsomal protein, cytochrome P-450, cytochrome b5, NADPH-cytochrome C reductase, aminopyrine demethylase and benzo(a)pyrine hydroxylase activities in mice. kopsinine only induced cytochrome P-450 in rough endoplasmic reticulum of liver. SDS-polyamine gel electrophoresis analysis showed that the protein bands of microsomes from kopsinine treated mice were similar to that induced by phenobarbital in mice. Metyrapon, a specific inhibitor of cytochrome P-450, partially antagonized aminopyrine demethylase activity of microsomes from mice treated with kopsinine. The results suggest that kopsinine yields a pentobarbital-like induction on liver mixed function oxidase in mice. In addition, kopsinine was found to shorten the barbital-induced sleeping time in mice.},
	issn = {1745-7254},	url = {}