@article{APS5499,
author = {Wei-qun Shen and Xin-yi Xu and Wei-wei Zhao and Zhao-xia Duan-mu and Zhi-min Yu and Xian-min Yu and Lu-yang Wang and Lu-yong Zhang},
title = {Dynamic changes in depolarization of action potentials by high frequency stimulation in guinea pig papillary muscles},
journal = {Acta Pharmacologica Sinica},
volume = {10},
number = {4},
year = {2016},
keywords = {},
abstract = {The effect of high frequency stimulation on rate-dependent depression of depolarization of action potentials was studied with computer and standard microelectrode techniques in guinea pig papillary muscles. After increasing driving frequency from 0.5 to 6 Hz, decreases in Vmax, APA and OS were found. Changes of upstroke velocity during phase 0 between driving frequency 6 and 0.5 Hz could be described as a parabola. The rate-dependent depression of depolarization was exaggerated by tetrodotoxin (TTX), particularly during the accelerating period of phase 0. A progressive decline in Vmax, which could be fitted by a power function curve, was observed after changing driving frequency from 1 to 5 Hz. TTX significantly influenced the decline in Vmax and the regression coefficients in fitted equations.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5499}
}