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Effects of dauricine on slow action potentials in myocardium

	author = {Xian-gang ZONG and Ming-xing JIANG},
	title = {Effects of dauricine on slow action potentials in myocardium},
	journal = {Acta Pharmacologica Sinica},
	volume = {11},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {The effects of dauricine were examined on the slow action potentials induced by both high K+ (24 mmol/L) or TTX (40 mumol/L) in guinea pig papillary muscles and in sinoatrial node cells of rabbit. Dauricine 40 mumol/L decreased the maximal upstroke velocity (Vmax) of slow action potentials and prolonged the action potential duration at 50% repolarization (APD50). Bay K 8644 (50 nmol/L) increased the amplitude and Vmax of slow action potentials, which were antagonized by dauricine (40 mumol/L). An inhibitory influence of dauricine on the action potential amplitude was observed in papillary muscles superfused with Tyrode's solution containing high K+ and in rabbit sinoatrial node cells, but it was not with TTX. The resting potentials of the 3 slow action potentials were not affected by dauricine. The results suggest that dauricine possesses calcium-antagonistic effect.},
	issn = {1745-7254},	url = {}