TY - JOUR AU - LU Xiao-dong AU - ZHAO Geng-sheng PY - 2016 TI - Effects of metoclopramide on Vmax of action potentials in guinea pig papillary muscles JF - Acta Pharmacologica Sinica; Vol 11, No 3 (May 1990): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - The effects of metoclopramide (MCP) on Vmax of action potentials of guinea pig papillary muscles were studied with intracellular microelectrodes. MCP 10-550 mumol/L abbreviated the action potential duration at 90% repolarization (APD90) and decreased the maximal rate of rise of action potential (Vmax) dose-dependently. MCP caused rate-dependent and voltage-dependent reductions of Vmax and retardation of the recovery of Vmax. The results present the possible causes of depressant effect of MCP on Na channel. UR - http://www.chinaphar.com/article/view/5484