@article{APS5484,
author = {Xiao-dong LU and Geng-sheng ZHAO},
title = {Effects of metoclopramide on Vmax of action potentials in guinea pig papillary muscles},
journal = {Acta Pharmacologica Sinica},
volume = {11},
number = {3},
year = {2016},
keywords = {},
abstract = {The effects of metoclopramide (MCP) on Vmax of action potentials of guinea pig papillary muscles were studied with intracellular microelectrodes. MCP 10-550 mumol/L abbreviated the action potential duration at 90% repolarization (APD90) and decreased the maximal rate of rise of action potential (Vmax) dose-dependently. MCP caused rate-dependent and voltage-dependent reductions of Vmax and retardation of the recovery of Vmax. The results present the possible causes of depressant effect of MCP on Na channel.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5484}
}