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Effects of neferine on heart electromechanical activity in anaesthetized cats

   
@article{APS5431,
	author = {Gui-rong LI and Jia-qing QIAN and Fu-hua LV},
	title = {Effects of neferine on heart electromechanical activity in anaesthetized cats},
	journal = {Acta Pharmacologica Sinica},
	volume = {11},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Neferine, an alkaloid extracted from the green seed embryo of Nelumbo nucifera Gaertn, has been shown to have anti-arrhythmic action. Neferine 1-10 mg/kg iv dose-dependently decreased the monophasic action potential amplitude (MAPA), prolonged the monophasic action potential duration (MAPD). It also decreased LVP, dP/dt, prolonged SCL, and reduced arterial blood pressure in a dose-dependent manner. These effects were similar to those of quinidine, and different from tetrandrine. The latter had an inhibitory effect on LVP and dP/dt, but had no influence on MAPA and MAPD. The results indicate that neferine and quinidine have similar effects on heart electro-mechanical activity.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5431}
}