@article{APS5384,
author = {Tian-ying GUAN and Xiang-yi GOGN and Wei-zhi SUN and Shu-zhen LIU and Lian-fang ZHENG and Ming-gui LI},
title = {Pharmacokinetics of albendazole and its metabolites in human body},
journal = {Acta Pharmacologica Sinica},
volume = {11},
number = {1},
year = {2016},
keywords = {},
abstract = {High-performance liquid chromatography method was used to determine blood sulfoxide and sulfone, two metabolites of albendazole. Methanol containing 0.4% acetic acid was employed as mobile phase. Wavelength of 290 nm was chosen for uv-detector and mebendazole was used as internal standard. After a single dosage of albendazole 25 mg/kg was taken orally by healthy volunteers and neurocysticercosis patients, sulfoxide and sulfone were found in blood at 20 and 40 min respectively. The blood peak level appeared at 6 h on an average. The metabolites remained as long as 58-72 h in human blood.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5384}
}