@article{APS5358,
author = {Qian LI and Jia-qing QIAN},
title = {Effects of alpha-adrenoceptor agonists on cardiac function and blood pressure in rats},
journal = {Acta Pharmacologica Sinica},
volume = {11},
number = {1},
year = {2016},
keywords = {},
abstract = {In rat working hearts, alpha 1-adrenoceptor agonist phenylephrine increased LVP, +/- dP/dtmax, ABF and HR in the presence of propranolol. But alpha 2-adrenoceptor agonist B-HT 920 was ineffective. The changes induced by phenylephrine were antagonized by prazosin. In normotensive pithed rats, iv methoxamine dose-dependently increased LVP, +/- dP/dtmax, LVEDP, SAP and DAP. The changes in haemodynamics elicited by iv methoxamine were also antagonized by pretreatment with prazosin, and were attenuated by nifedipine (1 mg/kg, ia). In these two experiments, the increase in HR developed more slowly. The results suggest that postjunctional alpha 1-adrenoceptors, which exist in rat myocardium, produce a positive inotropic effect, which is possibly dependent on influx of extracellular calcium. Postjunctional alpha 2-adrenoceptors-mediated effects were not found in rat myocardium in our functional studies.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5358}
}