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Effect of nisoldipine on cultured myocardial cells of neonatal rats

   
@article{APS5346,
	author = {Jia-cui Yang and Chuan-lin Yu and Jia-xin Zhang and Wei-xin Gu and Ming-xue Ding and Yu-fa Yao},
	title = {Effect of nisoldipine on cultured myocardial cells of neonatal rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {10},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Nisoldipine 1.5 nmol/L, 0.75, and 1.5 mumol/L depressed the beat rates of myocardial cells. The effects were negatively correlated with dosages. Nisoldipine depressed the beat rates increased by calcium chloride 0.15 mmol/L or isoprenaline 1.5 mumol/L and atropine 20 nmol/L. Conversely, the above drugs reversed the beat rates depressed by nisoldipine. Therefore, the acting nisoldipine may be antagonistic to calcium chloride, isoprenaline and atropine. In addition, nisoldipine 10 nmol/L may significantly aggravated the damage to myocardial cells induced by mitomycin C 5 micrograms/ml in which elevated lactate dehydrogenase appeared.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5346}
}