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Effects of an endogenous GABA receptor binding inhibitor on rat blood pressure

   
@article{APS5342,
	author = {Ning-sheng Cai and Wen-bin Xiao and Ting-chong Zhou},
	title = {Effects of an endogenous GABA receptor binding inhibitor on rat blood pressure},
	journal = {Acta Pharmacologica Sinica},
	volume = {10},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {The GABA receptor agonists GABA (400 micrograms icv) and muscimol (1 microgram icv) induced hypotension in urethane-anesthetized rats, while the GABA receptor antagonist bicuculline (2 micrograms icv) elicited hypertension. An endogenous GABA receptor binding inhibitor (1 mg), prepared from bovine cerebellum, showed bicuculline-like hypertensive action in a dose-dependent manner. It was antagonized by icv muscimol, but not by the alpha 2-adrenoceptor agonist clonidine. These in vivo results agree quite well with our previous in vitro receptor binding assay experiments.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5342}
}