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Effects of sodium beta-3,4-dihydroxyphenyl lactate and beta-phenyl lactic acid on prostacyclin and thromboxane A2 contents in plasma of rabbits after coronary artery occlusion

   
@article{APS5331,
	author = {Liang ZHU and Yi-de SHAO and Hua-juan DAI and Ji-chang DONG and Fen XUE},
	title = {Effects of sodium beta-3,4-dihydroxyphenyl lactate and beta-phenyl lactic acid on prostacyclin and thromboxane A2 contents in plasma of rabbits after coronary artery occlusion},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {This paper reports the effects of natural(+) sodium beta-3,4-dihydroxyphenyl lactate[(+)DHPL], synthetic (+/-) DHPL and (+/-)beta-phenyl lactic acid (PLA) on prostacyclin and thromboxane A2 contents in plasma of rabbits after occlusion of descending branch of coronary artery.
PLA and (+)DHPL (50 mg/kg iv) reduced elevation of S-T segment, but (+/-)DHPL (50 mg/kg iv) failed to do so. PLA, (+)DHPL and (+/-) DHPL reduced the production of thromboxane A2; (+)DHPL and (+/-)DHPL reduced prostacyclin production markedly, but PLA had no effect.
These results suggest that the action of PLA might be mainly to inhibit thromboxane synthetase.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5331}
}