@article{APS5329,
author = {Zhen-de ZHANG and Guo-zhang JIN and Shou-xi XU and Lei-ping YU and Yan CHEN and Fu-yin JIANG and Yan-ru ZHANG and Zhou SUN and Yue-li DING and Chun-fu BIAN and Wei QIN},
title = {Effects of l-stepholidine on central nervous and cardiovascular systems},
journal = {Acta Pharmacologica Sinica},
volume = {7},
number = {6},
year = {2016},
keywords = {},
abstract = {l-Stepholidine (SPD) is one of the analogs of l-tetrahydroprotoberberines (THPB). It has been shown that SPD is a dopamine receptor antagonist. In this work, it was further demonstrated that SPD antagonized apomorphine-induced stereotypy in rats and apomorphine-induced vomiting in dogs. SPD produced a transient catalepsy in mice, and it caused a marked decrement of Ach level in the caudatum. All the results support the view point that SPD is an antagonist of dopamine receptors.
On spontaneously activity in mice, SPD exhibited a diphasic action on amphetamine-effect. Following a brief antagonism, the potential effect of SPD on amphetamine was observed.
In the anesthetized dogs given SPD 40 mg/kg, a decrement of arterial blood pressure by 63% within 10 min and a marked reduction of total peripheral resistance were observed stimutaneously, but without any adverse effect on heart.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5329}
}