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Stimulative effect of substance P on insulin secretion from isolated rat islets under normobaric oxygen incubation

   
@article{APS5312,
	author = {Xiao-wen Fu and Anthony M Sun},
	title = {Stimulative effect of substance P on insulin secretion from isolated rat islets under normobaric oxygen incubation},
	journal = {Acta Pharmacologica Sinica},
	volume = {10},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {The effects of substance P (SP), physalaemin, and [D-Pro2, D-Phe7, D-Trp9]-SP on insulin release from isolated, cultured rat islets were investigated. Substance P stimulated insulin secretion in a dose-dependent manner at 0.1-100 nmol/L under one atmosphere of air with glucose 2.75, 5.5 and 20 mmol/L in the culture medium. Physalaemin 100 nmol/L was added to the culture medium, also stimulated insulin secretion. [D-Pro2, D-Phe7, D-Trp9]-SP 10 nmol/L reversed the stimulative effect of substance P. However, substance P 1 nmol/L inhibited insulin secretion from isolated rat islets under hyperbaric oxygen condations.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5312}
}