TY - JOUR AU - Li Yong-Qing AU - Xu Yuan-Xiu PY - 2016 TI - Effects of tetrandrine on ovum transport in rabbit oviduct JF - Acta Pharmacologica Sinica; Vol 8, No 6 (November 1987): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - On isolated oviductal isthmus of rabbits, tetrandrine (1-3 μmol/L) inhibited the spontaneous contraction and the contraction caused by phenylephrine. The pD’2 values of tetrandrine, measured on the oviduct of the rabbits pretreated with estradiol or megestrol, were 4.19 and 4.74, respectively. Tetrandrine 5 mg/kg iv suppressed the increasing intraluminal pressure in situ induced by phenylephrine (0.2 μg/kg). At 48 h after ovulation, tetrandrine delayed the ovum transport through the oviduct and suppressed the activity of ova accelerated by estradiol cyclopentylpropionate (25 μg). UR - http://www.chinaphar.com/article/view/5251