%0 Journal Article %T Central action of anti-arrhythmic effect of methylflavonolamine hydrochloride %A Wang Ming-Zhen %A Wan Bao-Song %A Zhou Er-Feng %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Central action of anti-arrhythmic effect of methylflavonolamine hydrochloride %K %X After 2 branches of anterior descending coronary artery were cauterized, the electrical stimulation of the posterior hypothalamus resulted in a consistent arrhythmia with hypertension, mydriasis and cardiac ischemia in rabbits. Methylflavonolamine-HCl (MFA) ia 0.5 mg/kg or iv 5 mg/kg prevented the arrhythmia and alleviated the cardiac ischemia. The arrhythmia in 9/9 rabbits was prevented by ia MFA 0.5 mg/kg, but not by iv. These results suggest that the anti-arrhythmic action of MFA, in addition to its direct action on heart, involves also the central mechanisms. %U http://www.chinaphar.com/article/view/5246 %V 8 %N 6 %P 513-516 %@ 1745-7254