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Central action of anti-arrhythmic effect of methylflavonolamine hydrochloride

   
@article{APS5246,
	author = {Ming-Zhen Wang and Bao-Song Wan and Er-Feng Zhou},
	title = {Central action of anti-arrhythmic effect of methylflavonolamine hydrochloride},
	journal = {Acta Pharmacologica Sinica},
	volume = {8},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {After 2 branches of anterior descending coronary artery were cauterized, the electrical stimulation of the posterior hypothalamus resulted in a consistent arrhythmia with hypertension, mydriasis and cardiac ischemia in rabbits. Methylflavonolamine-HCl (MFA) ia 0.5 mg/kg or iv 5 mg/kg prevented the arrhythmia and alleviated the cardiac ischemia. The arrhythmia in 9/9 rabbits was prevented by ia MFA 0.5 mg/kg, but not by iv. These results suggest that the anti-arrhythmic action of MFA, in addition to its direct action on heart, involves also the central mechanisms.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5246}
}