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Determination of sophoramine and sophocarpine in rabbit plasma by capillary column gas chromatography and their pharmacokinetics

  
@article{APS5213,
	author = {Xiao-Dong Liu and Sheng-Kai Huang and Hui-Nan Yuan},
	title = {Determination of sophoramine and sophocarpine in rabbit plasma by capillary column gas chromatography and their pharmacokinetics},
	journal = {Acta Pharmacologica Sinica},
	volume = {8},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {capillary column gas chromatography was proposed. The recovery of sophoramine from plasma was over 90%. There was a linear relationship between 0.5 and 10μg. The comparative pharmacokinetics of sophoramine and sophocarpine (iv 10 mg/kg) were studied in rabbits. Plasma concentration vs time data were described by an open two compartment model. The pharmacokinetic parameters of sophoramine and sophocarpine were as follows: Vc 0.72 and 1.40 L/kg; CL 17.0 and 28.2 ml/(kg·min-1);α 0.126 and 0.114 min-1;β 0.0136 and 0.00853 min-1, respectively. The differences in distribution volume, clearance and elimination rate constant of the drugs were significant (p},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5213}
}