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Effects of dimethyltrilobine iodide on isolated superior cervical ganglion of rabbits

   
@article{APS5182,
	author = {Yong-Xiao Cao and Xi-Ping Che and Bing-Xiang Yuan},
	title = {Effects of dimethyltrilobine iodide on isolated superior cervical ganglion of rabbits},
	journal = {Acta Pharmacologica Sinica},
	volume = {8},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {The effects of dimethyltrilobine iodide (DTI) were studied by the sucrose-gap method using curare for comparison. DTI at cumulative concentration inhibited ganglion action potentials. IC50 of DTI and curare were 82 and 30 μg/ml, respectively. The effects of DTI were antagonized by neostigmine, enhanced under Ca2+-free or 1/2[Ca2+] and reduced under 2[Ca2+]. DTI inhibited ganglionic N wave, P wave and LN wave.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5182}
}