TY - JOUR AU - Han Ba-Jin AU - Zhou Er-Feng AU - Wan Bao-Song AU - Tang Yun-Zhao AU - Yang Jia-Mei AU - Xie Mei-Hua PY - 2016 TI - Anti-arrhythmic effects of methylflavonolamine hydrochloride JF - Acta Pharmacologica Sinica; Vol 8, No 4 (July 1987): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Methylflavonolamine hydrochloride (MFA) showed anti-arrhythmic effects on (l) chloroform-induced ventricular fibrillation in mice with therapeutic indices of 4.1 (ip) and 5.3 (iv); (2) chloroformepinephrine or BaCl2 induced arrhythmias in rabbits: (3) aconitine-induced arrhythmias in rats. The electrophysiological effect of MFA on the hearts of rabbits were studied by suction electrode method in situ. At the therapeutic dose (5 mg/kg iv), APD50, APD90 and FRP were prolonged by 9.0±3.6 ms, 12.9±4.9 ms and 29.8±5.6ms, respectively. UR - http://www.chinaphar.com/article/view/5149