%0 Journal Article %T Effects of acetylgastrodin on vertebral and internal carotid artery blood flow in anesthetized dogs and rabbits %A Chen Zhi-He %A Zhang Zheng-Xian %A Wang Xin-Hua %A Xiang Jian-Ming %A Xiong Jian-Ming %A Mo Yun-Qiang %J Acta Pharmacologica Sinica %D 2016 %B 2016 %9 %! Effects of acetylgastrodin on vertebral and internal carotid artery blood flow in anesthetized dogs and rabbits %K %X Acetylgastrodin is a derivative of gastrodin which is an effective constituent of Gastrodia elata. In anesthetized dogs and rabbits, the hemodynamics with special reference to cerebral circulation were studied. Following intraduodenally administration of acetylgastrodin suspension 200 mg/kg to dogs, the vertebral artery flow increased at 10-60 min (+15-30%, p 0.05, n=8). Similarly, the internal carotid flow of rabbits markedly increased (+24-111%, n=8, p 0.05, n=8). However, in the same route, nicardipine 250 μg/kg caused a significant increase of internal carotid flow of rabbits (+41-88%, p<0.05, 0.01, n=8), with mild rise of cardiac output. These results suggest that the effects of acetylgastrodin on cerebral circulation seem to be selective. %U http://www.chinaphar.com/article/view/5145 %V 8 %N 4 %P 321-325 %@ 1745-7254