@article{APS5120,
author = {Yan-yong Liu and Ling Hu and Chao Ji and Dong-wen Chen and Xi Shen and Nan Yang and Yun Yue and Jing-mei Jiang and Xia Hong and Qin-sheng Ge and Ping-ping Zuo},
title = {Effects of hormone replacement therapy on magnetic resonance imaging of brain parenchyma hyperintensities in postmenopausal women},
journal = {Acta Pharmacologica Sinica},
volume = {30},
number = {7},
year = {2016},
keywords = {},
abstract = {Aim: To apply 3.0 magnetic resonance imaging (MRI) to study the effects of long-term, low dose hormone replacement therapy (HRT) on the brain parenchyma of postmenopausal women.
Methods: A total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital were enrolled. The HRT group was composed of 71 subjects who had been given a low dose of HRT for over 4 years, while 84 women who had never been given HRT were enrolled in the control group. The Mini-Mental State Examination (MMSE) was used to evaluate mental state, and an Enzyme-Linked ImmunoSorbent Assay (ELISA) was used to detect plasma levels of sex hormones. In addition, all participants were subjected to an MRI, including axial T2 weighted imaging (T2WI), fluid-attenuated inversion recovery (FLAIR), T1 weighted imaging (T1WI, oblique coronal, vertical to the hippocampus, slice thickness 3 mm without gaps), and a 3D image of the whole brain.
Results: The ELISA showed that the plasma level of estradiol in the HRT group was significantly higher than that in the control group (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5120}
}