@article{APS5089,
author = {Yu-feng Xie},
title = {Glial involvement in trigeminal central sensitization},
journal = {Acta Pharmacologica Sinica},
volume = {29},
number = {6},
year = {2016},
keywords = {},
abstract = {Recent studies have indicated that trigeminal neurons exhibit central sensitization, an increase in the excitability of neurons within the central nervous system to the extent that a normally innocuous stimulus begins to produce pain after inflammation or injury, and that glial activities play a vital role in this central sensitization. The involvement of glial cells in trigeminal central sensitization contains multiple mechanisms, including interaction with glutamatergic and purinergic receptors. A better understanding of the trigeminal central sensitization mediated by glial cells will help to find potential therapeutic targets and lead to developing new analgesics for orofacial-specific pain with higher efficiency and fewer side-effects.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5089}
}