@article{APS5088,
author = {Zheng-Qin Tao and Xin-Hua Xu and Xue-Ming Yan and Zhcn-Jia Chen and Jian-Shi Zhang and You-Yi Liang and Yu-Yuan Xie},
title = {Detoxication and mobilization of uranium by catecholamic acid},
journal = {Acta Pharmacologica Sinica},
volume = {8},
number = {3},
year = {2016},
keywords = {},
abstract = {Catecholamic acid [catechol-3,6-bis(methyleneimino diacetic acid), CBMIDA] is a chelating agent synthesized in our laboratory. CBMIDA was shown to be effective in treatment of uranium intoxication. CBMIDA sc 1 g/kg considerably increased the survival of mice acutely poisoned by ip uranyl nitrate (UN). All rats given im 0.1-0.5 g/kg CBMIDA lived 30 d after ip UN 40 mg/kg, while the control rats died within 7 d. The lethal dose of UN was significantly increased in rats after im CBMIDA 0.5 g/kg, therein CBMIDA was more effective than phosphicine. After ip UN (400μg U/rat) following im CBMIDA 0.1-0.5 g/kg or 0.5 g/kg daily for 2 d or ig 2 g/kg in rats, the excretion of uranium in urine was increased, the ratio was 1.76-2.50 in comparison with the control group. Within 2 wk, CBMIDA group showed less intoxication and renal damages than the control rats.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/5088}
}