TY - JOUR AU - Chen Xing-Jian AU - Fan Hong-Ying AU - Yao Yu-Fa AU - Zhang Jia-Xing AU - Gu Wei-Xing AU - Liu Xiao-Ming AU - Liu Ju-Fang PY - 2016 TI - Relation of antihypertensive effect and central α-adrenocptor of rhomotoxin JF - Acta Pharmacologica Sinica; Vol 8, No 3 (May 1987): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - Rhomotoxin 8μg/kg iv caused a decrease of arterial blood pressure in rabbits. Small doses 1.2μg/kg also showed antihypertensive effect when injected intracerebroventricularly but not when given intravenously. The antihypertensive effect of rhomotoxin 1.2μg/kg icv was partially antagonized by theα-adrenoceptor blocker phentolamine 50μg icv andα1 blocker prazosin 30μg icv and completely antagonized byα2 blocker yohimbine 50μg icv. The plasma renin activity of rats was suppressed 25.8% by rhomotoxin. These results suggest that the antihypertensive effect of thomotoxin is closely related to centralα2 -adrenoceptors. UR - http://www.chinaphar.com/article/view/5071