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Effect of 3-aminobenzamide on DNA replication and DNA repair synthesis in S180 cells

   
@article{APS5047,
	author = {Guan CHEN and Qi-chao PAN},
	title = {Effect of 3-aminobenzamide on DNA replication and DNA repair synthesis in S180 cells},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {To elucidate the mechanism by which 3-aminobenzamide (3-AB) enhanced the antitumor effect of bleomycin A5 (BLMA5) on S180. We studied the effects of 3-AB on the DNA-replication synthesis and DNA-repair synthesis both in untreated and BLMA5-treated S180 cells. 3-AB 2 mM stimulated DNA-repair synthesis after the cells were exposed to BLMA5 for 30 min, but 5 and10 mM inhibited DNA-replication synthesis and enhanced the inhibition of DNA-replication synthesis by BLMA5 respectively.
3-AB affected DNA-repair synthesis more rapidly than DNA-replication. The results indicate that more than one mechanism are involved in the above-mentioned process.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5047}
}