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Analgesic and antipyretic effects of l-stepholidine without addiction

   
@article{APS5021,
	author = {Lin-fang CHEN and Ju-zhen GAO and Fang-cai WANG},
	title = {Analgesic and antipyretic effects of l-stepholidine without addiction},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {l-Stepholidine (St), an alkaloid isolated from Stephania longipes, showed no anticonvulsive action on mice induced by pentylenetetrazol. St 50 mg/kg ig showed antipyretic actions on rabbits induced by typhoparatyphoid vaccine. St 50 (mg/kg)* 5  ip in mice did not induce physical dependence as found with morphine. After St 2.5-35 mg/kg ip*7 within 2 d and then challenged with nalorphine 50 mg/kg, the mice showed no jumping response. In morphine-addicted rats, their body weights were restored after morphine sc but not after l-stepholidine.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5021}
}