TY - JOUR AU - YE Yi-xin AU - BI Xiao-feng AU - ZHENG Yun-juan AU - YANG Hui-fen PY - 2016 TI - Mode of inhibitory action of gossypol on Na+, K+-ATPase in vitro JF - Acta Pharmacologica Sinica; Vol 7, No 3 (May 1986): Acta Pharmacologica Sinica Y2 - 2016 KW - N2 - When ouabain was applied in combination with gossypol, the inhibitory effect of both gossypol and ouabain on Na+, K+-ATPase activity was antagonistic. The kinetic studies of gossypol on [3H] ouabain binding to Na+, K+-ATPase showed that gossypol decreased both Kd and the Bmax values uncompetitively, whereas digoxin decreased competitively. K+ did not affect the action of gossypol on [3H]ouabain binding to Na+,K+-ATPase. UR - http://www.chinaphar.com/article/view/5008