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Mode of inhibitory action of gossypol on Na+, K+-ATPase in vitro

   
@article{APS5008,
	author = {Yi-xin YE and Xiao-feng BI and Yun-juan ZHENG and Hui-fen YANG},
	title = {Mode of inhibitory action of gossypol on Na+, K+-ATPase in vitro},
	journal = {Acta Pharmacologica Sinica},
	volume = {7},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {When ouabain was applied in combination with gossypol, the inhibitory effect of both gossypol and ouabain on Na+, K+-ATPase activity was antagonistic.
The kinetic studies of gossypol on [3H] ouabain binding to Na+, K+-ATPase showed that gossypol decreased both Kd and the Bmax values uncompetitively, whereas digoxin decreased competitively.
K+ did not affect the action of gossypol on [3H]ouabain binding to Na+,K+-ATPase.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/5008}
}